Cardio Round-Up: Cardiac Variants Linked to Sudden Death in Young People; and More

Genomic Autopsy Finds Cardiac Variants in Young, Sudden Death Patients

Postmortem genetic testing identified pathogenic/likely pathogenic (P/LP) cardiac genetic variants in arrhythmia or cardiomyopathy genes in approximately 13% of young individuals with sudden death, according to a study published in JAMA Cardiology. Researchers of this study sought to assess both the genotypic and phenotypic risk of sudden death in a diverse cohort of young decedents and their families. The study comprised 103 decedents (mean age at death, 23 years), their surviving family members, as well as 140 sex- and genetic ancestry–matched controls. “Whole-genome sequencing effectively identified P/LP variants in cases of sudden death in young individuals, implicating both arrhythmia and cardiomyopathy genes,” the researchers concluded.

Mobil-O-Graph Monitor Identifies Several Parameters Linked with PAD

Total vascular resistance (TVR), augmentation pressure (AP), and augmentation index (AI) are notably higher in peripheral arterial disease (PAD), according to a study published in Medicine. According to the results, in PAD group, the systolic brachial BP and central systolic BP were significantly higher than those in the non-PAD group. The researchers observed that TVR, AI, and AP were significantly higher in the PAD group.

Study Finds a Link Between Heart Failure and Long-Term Risk of VTE

Heart failure (HF) is an independent risk factor for venous thromboembolism (VTE) and pulmonary embolism (PE), but not deep vein thrombosis (DVT), according to a study published in Korean Circulation Journal. In this study, researchers assessed 31 studies consisting of over 530,641 HF patients with data obtained studies investigating the risk of VTE, PE, and DVT in patients with HF before April 15, 2020, in PubMed, MEDLINE, and Embase databases investigating the risk of VTE, PE, and DVT in patients with HF before April 15, 2020. “In conclusion, HF was an independent risk for VTE and PE but not DVT in the long-term follow-up period. Patients with chronic HF were prone to have a higher risk of VTE,” the researchers wrote.

Clinical Decision Support Software May Improve Atrial Fibrillation Outcomes

Researchers developed a clinical decision support (CDS) tool that may help primary care providers (PCPs) deliver individualized guideline-based atrial fibrillation (AF) care. The findings were published in BMC.