Adolescent Cancer Survivors Face Increased Risk of Endocrine Disease

A study published in JAMA found that adolescent and young adult cancer survivors had a 73% higher risk for endocrine diseases compared with a matched population that did not have cancer. 

This nationwide, population-based Danish cohort study followed patients from January 1, 1977, to December 31, 2010. They used the Danish Cancer Registry to identify 32,548 one-year cancer survivors diagnosed between 15 and 39 years and matched them based on year of birth and sex with 188,728 cancer-free participants who were randomly selected from the Danish Civil Registration system.  

A total of 2,129 survivors (6.5%) had at least one hospital contact for an endocrine disease, while 1,232 (3.8%) of the background population were expected to have done so (hospitalization rate ratio [RR] = 1.73). RRs were highest for testicular hypofunction, ovarian hypofunction, and pituitary hypofunction. The leading reasons for hospital visits were thyroid disease (38%), testicular dysfunction (17.1%), and diabetes (14.4%).  

Leukemia survivors had a high risk for any endocrine disease, and Hodgkin lymphoma survivors had the highest disease-specific excess risk for hypothyroidism. 

Source: JAMA