Here are the top stories covered by DocWire News featuring novel uses of the CRISPR Gene Editing Technology. This edition includes quickly detecting Gene Mutations, Curing Disease, Malaria, deafness and more. Read below and stay tuned for more on this exciting topic.
1:CRISPR-Chip Accurately Detecting Genetic Mutations in Minutes
Engineers from the UC Berkeley and the Keck Graduate Institute (KGI) of The Claremont Colleges have recently used CRISPR to create a sensor that detects specific genetic mutations in minutes. The researchers are calling the device CRISPR-Chip, and feel that it could potentially provide rapid diagnosis of genetic diseases, or evaluate accuracy of genetic editing efforts.
2: CRISPR-cas gene-editing as plausible treatment of neuromuscular and nucleotide-repeat-expansion diseases: A systematic review
The system of clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (cas) is a new technology that allows easier manipulation of the genome. Its potential to edit genes opened a new door in treatment development for incurable neurological monogenic diseases (NMGDs). The aim of this systematic review was to summarize the findings on the current development of CRISPR-cas for therapeutic purposes in the most frequent NMGDs and provide critical assessment.
3: UK Researchers Use CRISPR Genome Editing to Eliminate Malaria in Study
A group of researchers from Imperial College in London have recently conducted a study in which CRISPR-Cas9 genomic editing was used to eliminate malaria-infected mosquitoes. In their findings published in Nature Biotechnology, scientists were able to eradicate a controlled population of mosquitoes in as few as 7 reproductive generations. The project was funded in part by the Bill and Melinda Gates Foundation, the UK’s Biotechnology and Biological Sciences Research Council, and the Massachusetts General Hospital program.
4: Researchers Use Gene Therapy to Treat Deafness in Animal Model
Gene therapy has recently been used to restore hearing in a mouse model of deafness that represents one of the most common genetic causes of the condition. Referred to as DFNB9 deafness, the condition results in a deficiency in the gene coding for otoferlin, a protein with a key role in transmitting signals at the synapses of auditory sensory cells. By administering an intracochlear injection of this gene to model animals, the researchers found that auditory neural activity and hearing functions were restored to a near-normal level.
5: Novel CRISPR-Cas3 Genetic Editing Holds Potential in Curing Disease
A new gene editing system, called CRISPR-Cas3 has been developed by a group of researchers that that can erase long DNA stretches from sites in the human genome. This is a capability that is not easily accomplished through traditional CRISPR-Cas9 systems. This new approach to genetic editing has the capability to find and erase ectopic viruses such as herpes simplex, hepatitis B, and Epstein-Barr, each poses significant detriments to health. These findings were published in a paper on April 8 in the journal Molecular Cell.