From April to December, there was a significant decline in the number of Americans who say they are willing to get a COVID-19 vaccine, according to a research letter published online Dec. 29 in the Journal of the American Medical Association.
Peter G. Szilagyi, M.D., from the University of California in Los Angeles, and colleagues conducted a biweekly online survey (8,167 participants; April 1 to 14 through Nov. 25 to Dec. 8) to assess trends in the public’s likelihood of getting a COVID-19 vaccine.
“Low likelihood of getting a COVID-19 vaccine among Black individuals and those with lower educational backgrounds is especially concerning because of their disproportionately higher burden from COVID-19 disease,” the authors write.
While the Omicron variant appears wily enough to evade people’s antibodies, researchers report that it should have a much harder time slipping past a person’s T-cells.
The researchers analyzed more than 1,500 fragments of SARS-CoV-2’s viral proteins called epitopes, which have been found to be recognized by T-cells in recovered COVID-19 patients or after vaccination.
“Despite being a preliminary study, we believe this is positive news. Even if Omicron, or some other variant for that matter, can potentially escape antibodies, a robust T-cell response can still be expected to offer protection and help to prevent significant illness,” said study co-leader Matthew McKay, from the University of Melbourne in Australia.
Immune Response Rate In Dialysis Patients after SARS-CoV-2 Vaccination
Risk of mortality among adults on dialysis who are infected with SARS-CoV-2 is higher than that among adults not receiving dialysis. The majority of clinical trials of patients with SARS-CoV-2 infection have not included patients with end-stage kidney disease (ESKD); in patients in that population, the efficacy of SARS-CoV-2 vaccines is assessed using immunogenicity.
To date, there have been few systematic reviews of the immunogenicity rates of patients receiving dialysis. Ja-Jen Chen, MD, and colleagues conducted a systematic review and meta-analysis to investigate immunogenicity rates among patients with ESKD following receipt of SARS-CoV-2 vaccines. The study also examined potential risk factors for vaccine nonresponse and significant differences in antibody response rates between adults receiving dialysis and those not receiving dialysis. Results were reported online in JAMA Network Open.
More than 1.1 million American kids were diagnosed with COVID-19 during the week ending Jan. 20, new data show.
That’s 17% higher than the 981,000 cases diagnosed the week before and double the number from two weeks before that.
“As we approach the two-year anniversary of the pandemic, cases of COVID-19 among children and adolescents are the highest they have ever been,” said Dr. Moira Szilagyi, president of the American Academy of Pediatrics (AAP). “These numbers are staggering.”