Lowering Lipoprotein(a) in CVD Patients with High Lipoprotein(a)

Sotirios Tsimikas, MD, of the University of California San Diego, talks with DocWire News about experimental agents that lower lipoprotein(a) [LP(a)], a genetic risk factor for atherosclerotic cardiovascular disease in patients with established cardiovascular disease (CVD).

In this interview, he discusses results from his recent phase II, placebo-controlled study, in patients with high levels of Lp(a), treated with AKCEA-APO(a)-LRx, as well as other potential PCSK9 inhibitors such as evolocumab. The objective of the phase 2 trial was to determine the optimal dose and regimen of AKCEA-APO(a)-LRx for further clinical development. The trial was randomized, double-blind, placebo-controlled, dose-ranging trial designed to test the safety and efficacy of AKCEA-APO(a)-LRx injected subcutaneously. It included 286 CVD patients randomized (5:1) to 5 parallel cohorts treated with 5 different dosing regimens. Patients were treated for at lest 6 months, with a primary efficacy endpoint of percent change in Lp(a) from baseline.

Click the image to watch the full interview for the discussion of the results.

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