Potential prognostic value of miR-132 and miR-212 expression in mCRPC patients

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Arch Ital Urol Androl. 2021 Oct 4;93(3):373-374. doi: 10.4081/aiua.2021.3.373.


To the Editor, we have been very pleased to read the interesting work proposed by Salemi et al. regarding the expression of specific fragments of microRNA (miRNA), particularly miR-132 and miR-212, as potential key regulators in prostate cancer (PCa). As outlined by the Authors, the altered expression of miRNAs in cancer pathogenesis represents a well-consolidated knowledge in the current literature. More specifically, both miR-212 and miR-132 regulate subsets of genes involved in tumor progression in several tumor cell types as PCa, proving a central role in tumorigenesis, cell adhesion, and angiogenesis. In addition, a strong association between miR-132 expression and high Gleason score PCa has been lately depicted […].

PMID:34839648 | DOI:10.4081/aiua.2021.3.373