Radionuclide Imaging of Cardiac Amyloidosis

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PET Clin. 2021 Feb 12:S1556-8598(20)30105-X. doi: 10.1016/j.cpet.2020.12.010. Online ahead of print.


This article provides a review of the latest radiotracers for planar/single-photon emission computed tomography (SPECT) and positron emission tomography (PET)/computed tomography (CT) imaging of cardiac amyloidosis, detailing their affinity, specificity, and sensitivity for cardiac amyloidosis. There are several tracers available that have differing affinities for transthyretin (ATTR) and immunoglobulin light chain (AL), and new developments in technology have allowed for disease burden quantification. Bone scintigraphy is an excellent option for visualizing ATTR cardiac amyloidosis. Negative testing does not exclude the possibility of AL cardiac amyloidosis and absolute quantitation of amyloid burden is limited.

PMID:33589384 | DOI:10.1016/j.cpet.2020.12.010