STIC2IT: Tailored Medication Intervention Improves Adherence

A remotely delivered multicomponent intervention behaviorally tailored to each patient improved medication adherence, but not clinical outcomes, results of the STIC2IT trial suggested. 

The study, published in Annals of Internal Medicine, looked at 4,078 adults with poorly controlled disease (hyperlipidemia, hypertension and diabetes) who were also nonadherent to medication. Patients received either a tailored intervention that included telephone-delivered behavioral interviewing by pharmacists, pill boxes, text messages and progress reports, or usual care. Seven of the study’s 14 sites were randomized to the intervention. The primary study outcome was medication adherence via pharmacy claims data. 

According to the results, the tailored intervention was associated with a 4.7% (95% CI, 3.0%-6.4%) improvement in medication adherence compared to usual care. There were no differences in the odds of achieving adequate disease control, however, for at least one or all of the patient conditions. Patients receiving the intervention were less likely to have an emergency department visit. An as-treated analysis showed that the tailored intervention was associated with a 10.4% adherence increase.    

A multicomponent, technologically enabled pharmacist intervention tailored to patients’ adherence barriers and level of health activation improved medication adherence for patients with common, chronic conditions but did not change clinical outcomes,” the researchers wrote. “Future work should focus on identifying which groups derive the most clinical benefit from adherence to improvement efforts.”

Source: JAMA Internal Medicine