Pooled Cohort Equations Can Predict 10-year Atherosclerotic Cardiovascular Disease Risk

Pooled cohort equations (PCEs) can predict 10-year atherosclerotic cardiovascular disease risk (ASCVD) when events identified by the Centers for Medicare and Medicaid Services (CMS) were factored in, according to data published in a new analysis in JAMA Internal Medicine.  

The researchers looked at a cohort 19,995 women and evaluated the predictive accuracy of PCEs in the Women’s Health Initiative, the effects of aspirin and statins, and also looked at additional ASCVD events reported to CMS. The authors defined atherosclerotic cardiovascular disease as myocardial infarction, stroke, or cardiovascular death for the study outcome. The median follow-up was 10 years.  

According to the study data, a total of 1,236 atherosclerotic cardiovascular disease events occurred over 10 years. Women’s Health Initiative-adjudicated observed risks were lower than predicted, with small changes after adjusting for statin and aspirin use. In Medicare patients over 65 years of age, Women’s Health Initiative-adjudicated risks were lower than predicted but were more closely aligned with observed risk when events ascertained by CMS were included. These results were also seen across racial and ethnic groups. 

DocWire News has previously written about cardiovascular issues facing women, such as preeclampsia and increased risk, as well as other topics such as marital status and cardiovascular risk.  

Source: JAMA Internal Medicine