Eur J Neurol. 2022 Jun 2. doi: 10.1111/ene.15431. Online ahead of print.
BACKGROUND: Impaired kidney function is associated with an increased risk of vascular events in acute stroke patients, when assessed by single measurements of estimated glomerular filtration rate (eGFR). It is unknown whether repeated measurements provide additional information for risk prediction.
METHODS: The Systematic Monitoring for Detection of Atrial Fibrillation in Patients with Acute Ischemic Stroke (MonDAFIS) study randomly assigned 3,465 acute ischemic-stroke patients to either standard procedures or an additive Holter-ECG. Baseline eGFR (CKD-epi formula) were dichotomized into values <vs.≥60ml/min/1.73m2 . eGFR dynamics were classified based on two in-hospital values: “stable normal” (≥60ml/min/1.73m2 ), “increasing” (by at least 15% from baseline, 2nd value ≥60ml/min/1.73m2 ), “decreasing” (by at least 15% from baseline ≥60ml/min/1.73m2 ), and “stable decreased” (<60ml/min/1.73m2 ). The composite endpoint (stroke, major-bleeding, myocardial-infarction, all-cause death) was assessed after 24 months. We estimated hazard ratios in confounder adjusted models.
RESULTS: eGFR at baseline was available in 2,947 and a 2nd value in 1,623 patients. After adjusting for age, stroke severity, cardiovascular risk factors, and randomization, eGFR <60ml/min/1.73m2 at baseline (HR 2.2; 95%CI 1.40-3.54) as well as “decreasing” (HR 1.79; 95%CI: 1.07-2.99) and “stable decreased” eGFR (HR 1.64; 95%CI: 1.20-2.24) were independently associated with the composite endpoint. In addition, eGFR<60ml/min/1.732 at baseline (HR 3.02; 95%CI: 1.51-6.10) and “decreasing” eGFR were associated with all-cause death (HR 3.12; 95%CI: 1.63-5.98).
CONCLUSIONS: In addition to patients with low eGFR levels at baseline also those with decreasing eGFR have an increased risk for vascular events and death, hence, repeated estimates of eGFR might add relevant information to risk prediction. Trial registration number Clinicaltrials.gov NCT02204267.