SHOCK-COOL: Hypothermia Doesn’t Improve Cardiogenic Shock

Therapeutic hypothermia applied to patients with cardiogenic shock complicating acute myocardial infarction did not provide additional benefit, a new recent study from Circulation suggested. 

Researchers for the Mild Hypothermia in Cardiogenic Shock Complicating Myocardial Infarction (SHOCK-COOL) trial enrolled 40 patients with cardiogenic shock following acute myocardial infarction who were undergoing percutaneous coronary intervention and randomized them 1:1 to either mild therapeutic hypothermia for 24 hours or usual care. The primary study endpoint was cardiac power index at 24 hours.  

According to the results, there were no observed relevant differences in cardiac power index at 24 hours (0.41 in the hypothermia group versus 0.36 in the control group; P=0.50, median difference -0.025 [95%CI, -0.12 to 0.06 W/m2]. There were no reported differences in any other hemodynamic measurement, and there was no difference reported mortality (P=0.55) between the study groups.  

“In this randomized trial mild therapeutic hypothermia failed to show a substantial beneficial effect in patients with cardiogenic shock after acute myocardial infarction on cardiac power index at 24 hours,” the authors wrote concluded. 

Source: Circulation