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We have with great interest read the comment from Liccardi et al1 on our article recently published in the Journal.2 We share the opinion that the male dog allergen Can f 5 is an intriguing molecule that deserves further investigation. Sensitization to Can f 5 has in several studies been shown to play a role in respiratory allergy and it is known that monosensitization to Can f 5 occurs in a considerable proportion of dog dander–sensitized individuals. In the current study of dog dander–sensitized children we found that monosensitization to Can f 5 was associated with a negative nasal provocation test (NPT) result with dog dander extract (odds ratio, 5.78; 95% CI, 1.01-33.0).