Some of us are most at risk: Systematic Review and Meta-Analysis of correlates of depressive symptoms among healthcare workers during the SARS-CoV-2 outbreak

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Neurosci Biobehav Rev. 2021 Oct 13:S0149-7634(21)00452-8. doi: 10.1016/j.neubiorev.2021.10.010. Online ahead of print.


The COVID-19 pandemic has had a severe psychosocial impact on healthcare workers (HCWs). This systematic review and meta-analysis aimed at evaluating the association between individual features and depressive symptoms reported by HCWs during the pandemic. We searched Medline, Embase, and PsycInfo up to 23 June 2020. We included cross-sectional studies testing the association between individual correlates and depressive symptoms in HCWs during the SARS-CoV-2 outbreak. Fourteen studies met inclusion criteria, involving 14,173 HCWs (3,070 with depressive symptoms). Women (OR = 1.50; 95%CI: 1.28-1.76; I2 = 40.0%), individuals with suspected/confirmed COVID-19 (OR = 2.10; 95%CI: 1.64-2.69; I2 = 0%), and those with an infected family member or friend (OR = 1.67; 95%CI: 1.37-2.04; I2 = 0%) were more likely to report depressive features, which, instead, were less frequent among doctors (compared with nurses) (OR = 0.80; 95%CI: 0.66-0.98; I2 = 48.2%) and HCWs who felt adequately protected (OR = 0.48; 95%CI: 0.32-0.72; I2 = 36.3%). Our study provides timely evidence on the correlates of depressive symptoms among HCWs during the pandemic. Early screening is crucial to develop tailored health interventions, redesigning the response to COVID-19.

PMID:34655656 | DOI:10.1016/j.neubiorev.2021.10.010