Pain mechanisms in low back pain: A systematic review with meta-analysis of mechanical quantitative sensory testing outcomes in people with nonspecific low back pain

Six databases were looked into, for appropriate literature and 24 studies contrasting mechanical quantitative sensory testing (QST) measures including individuals with subacute and chronic low back pain (LBP) and healthy controls were involved in order to investigate whether sensory function, measured with QST, was changed in individuals with nonspecific LBP. Scores on the Newcastle-Ottawa scale ranged between one and six points. In comparison with healthy controls, individuals with nonspecific LBP, had markedly lower pressure pain thresholds (PPTs) at remote sites and raised temporal summation at the lower back. In individuals with nonspecific LBP vs healthy controls, the PPTs measured at the scapula were considerably lower. Therefore, at remote body parts, the PPT measurements were significantly lower in individuals with nonspecific LBP in comparison with healthy controls. Moreover, temporal summation and conditioned pain modulation measurements yielded mixed outcomes.