p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis

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Mol Cell Oncol. 2020 Sep 8;7(6):1805095. doi: 10.1080/23723556.2020.1805095.

ABSTRACT

Loss of tumor protein p53 (p53) and RB transcriptional corepressor 1 (RB1) in developmental and small cell lung cancer models promotes primary cilia formation and hyper-responsiveness to Hedgehog ligand. This is mediated by impaired transcription of p53 and RB1 target genes involved in autophagic degradation of primary cilia.

PMID:33235907 | PMC:PMC7671054 | DOI:10.1080/23723556.2020.1805095