Outcomes of Acute Myocardial Infarction in Patients with Rheumatoid Arthritis


There is paucity of data on the outcomes of acute myocardial infarction in patients with rheumatoid arthritis in the contemporary era.


We queried the National Inpatient Sample database (2002-2016) for hospitalizations with acute myocardial infarction. We described the trends and outcomes of acute myocardial infarction-rheumatoid arthritis compared with acute myocardial infarction-no rheumatoid arthritis.


The analysis included 9,359,546 hospitalizations with acute myocardial infarction, of whom 123,783 (1.3%) had rheumatoid arthritis. There was a rise in the number of hospitalizations with acute myocardial infarction-rheumatoid arthritis (Ptrend<0.001). There was an observed downtrend in mortality rates for acute myocardial infarction-rheumatoid arthritis (5.8% in 2002 versus 5.2% in 2016, Ptrend=0.01) corresponding to a rise in the utilization of percutaneous coronary intervention (Ptrend<0.001). In the overall cohort of acute myocardial infarction, rheumatoid arthritis was independently associated with lower rate of in-hospital mortality (adjusted odds ratio =0.90; 95%CI: 0.81-0.99, p=0.03). Compared with ST-elevation myocardial infarction (STEMI)-no rheumatoid arthritis, STEMI-rheumatoid arthritis was associated with lower in-hospital mortality and cardiac arrest, while it was associated with higher discharges to nursing facility. No difference in mortality was observed among Non-ST-elevation myocardial infarction (NSTEMI)-rheumatoid arthritis and NSTEMI-no rheumatoid arthritis, while NSTEMI-rheumatoid arthritis was associated with lower cardiac arrest, cardiogenic shock and hemodialysis, at the expense of higher bleeding events and discharges to nursing facilities.


In this nationwide analysis, we found an increase in hospitalizations for acute myocardial infarction-rheumatoid arthritis. Among patients with acute myocardial infarction, rheumatoid arthritis was independently associated with lower in-hospital mortality, particularly in cases of STEMI.