Kidney Transplantation From SARS-CoV-2 Positive Deceased Donor

This article was originally published here

Am J Transplant. 2021 Dec 3. doi: 10.1111/ajt.16905. Online ahead of print.

ABSTRACT

To expand the available donor pool, many organ procurement organizations and transplant programs have begun to consider severe acute respiratory syndrome coronavirus(SARS-CoV-2) nucleic acid test positive candidates(1). It is becoming increasingly clear that not all donors with a positive nucleic acid amplification test for SARS-CoV-2 are contagious, and some of these organs can be transplanted with careful selection(2, 3). Data from 31 kidney transplants from living donors with resolved COVID-19 in India showed the safety of this approach(4). However, it is unknown whether kidneys from donors with active COVID-19 can also be safely transplanted(3, 5). Beyond the “active” infection designation, it is clinically possible to risk stratify donors with COVID-19 based on additional parameters such as clinical history and radiologic or laboratory findings. Here we present a case and 210-day outcome of a successful kidney transplantation from otherwise medically suitable SARS-CoV-2 PCR positive deceased donors.

PMID:34859572 | DOI:10.1111/ajt.16905