Disturbances in brain energy metabolism in insulin resistance and diabetes and Alzheimer’s disease – Learnings from brain imaging biomarkers

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Int Rev Neurobiol. 2020;154:111-130. doi: 10.1016/bs.irn.2020.02.011. Epub 2020 Jul 11.

ABSTRACT

Medical imaging techniques, such as structural and functional magnetic resonance imaging and positron emission tomography, have been used to gain a better understanding of the alterations of the metabolic processes in the brain relating to type 2 diabetes melltius, insulin resistance and Alzheimer’s disease. These studies have shown that there are several similarities in the effects that these seemingly disparate diseases have on the brain, and that some of the abnormalities are reversed by metabolic interventions. This review provides an overview of the overlap between these diseases using medical imaging, focusing on glucose metabolism, mitochondrial function and lipid metabolism.

PMID:32739001 | DOI:10.1016/bs.irn.2020.02.011