Clinical characteristics of chronic nodular prurigo are independent of Fitzpatrick skin type. A European prospective cross-sectional study

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J Eur Acad Dermatol Venereol. 2021 Oct 17. doi: 10.1111/jdv.17756. Online ahead of print.


Chronic nodular prurigo (CNPG; syn.: prurigo nodularis) is a severe pruritic condition characterized by extensive scratching. Recent studies suggest racial disparities in the clinical profile of chronic itch1 and CNPG. African Americans are at higher risk to develop CNPG, show greater emotional impact to itch, but resort less to a dermatologist compared to whites.2, 3 Physiological cutaneous factors, such as higher trans-epidermal water loss, lower ceramide levels, varying pH levels and increased mast cells may contribute to more severe itch in black patients.4 No studies investigating racial disparities in CNPG patients have been performed in Europe. To close this gap we analyzed possible differences in the clinical profile, burden and care of CNPG patients of different skin types in a prospective cross-sectional study. This study is part of the European Prurigo Project; other data generated from this project has been previously published.5,6.

PMID:34661933 | DOI:10.1111/jdv.17756