Cannabis use disorder among atrial fibrillation admissions, 2008-2018

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Pacing Clin Electrophysiol. 2021 Sep 10. doi: 10.1111/pace.14356. Online ahead of print.


BACKGROUND: Despite changes in the legality of cannabis use and the increasing prevalence of cannabis use disorder (CUD), there is little data investigating the association between CUD and inpatient atrial fibrillation (AF) hospitalizations.

METHODS: Using the National Inpatient Sample, we identified AF hospitalizations with and without a co-diagnosis of CUD using International Classification of Diseases diagnosis codes and compared demographics, socioeconomics, comorbidities, outcomes, and trends between cohorts.

RESULTS: Between 2008 and 2018, we identified 5,155,789 admissions for AF of which 31,768 (0.6%) had a co-diagnosis of CUD. The proportion of admissions with a history of CUD increased from 0.3% in 2008 to 1.0% in 2018 (p<0.001). Hospital discharges of patients with CUD were significantly younger (53 years vs. 72 years, p<0.001), had a higher proportion of black race (CUD: 26.6% vs. 8.0%, p<0.001) and had a higher proportion of income in the lowest income quartile than without a co-diagnosis of CUD (CUD: 40.5% vs. 26.2%, p<0.001).

CONCLUSIONS: CUD is increasingly prevalent among AF hospitalizations, particularly among young patients. Co-diagnosis of CUD in AF hospitalizations also is more common in underserved patients. As a result, it is important for future research to examine and understand the impact of CUD on this population, particularly in the light of changing legislation surrounding the legality of cannabis. This article is protected by copyright. All rights reserved.

PMID:34506639 | DOI:10.1111/pace.14356