Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus

This article was originally published here

medRxiv. 2021 Apr 13:2021.04.09.21255184. doi: 10.1101/2021.04.09.21255184. Preprint.

ABSTRACT

To date the locus with the most robust human genetic association to COVID-19 susceptibility is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putative causal genes that mediate COVID-19 risk and highlight the usefulness of this integrative approach to bridge the divide between correlational and causal studies of human biology.

PMID:33880488 | PMC:PMC8057256 | DOI:10.1101/2021.04.09.21255184