Effects of Exercise on People with Hemophilia: Review of Systematic Reviews and Meta-Analyses

Exercise is an effective way to treat people with hemophilia (PWH) and has a low incidence of related adverse events, according to the findings of a study published in the journal Hemophilia.

“There is considerable evidence to indicate that exercise can have a positive impact on the treatment of (PWH),” the researchers wrote in their abstract. “However, there is a requirement for in‐depth and comprehensive studies.”

To conduct this umbrella review, which followed Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, the researchers combed PubMed, Web of Science, SPORTDiscus, Scopus, CINAHL and Cochrane Library databases. They identified a total of 1,030 systematic reviews, of which 10 met their inclusion criteria. The researchers determined that only one of these studies were high quality, with half of the selected studies deemed as low or critically low quality according to the according to AMSTAR 2 guidelines.

The study results revealed that most reviews investigated the effects of strength training and aquatic training, and these showed positive results associated with low adverse event with range of motion, strength, pain found as the most investigated variables. The researchers observed that all reviews showed overlapping studies.

The authors wrote in their conclusion that despite the positive link between exercise and low incidence of adverse events in PWH, “caution is needed in the interpretation of the results due to half of the selected reviews showed low or critically low quality and only one have high quality.”

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