We have developed a deep generative model, generative tensorial reinforcement learning (GENTRL), for de novo small-molecule design. GENTRL optimizes synthetic feasibility, novelty, and biological activity. We used GENTRL to discover potent inhibitors of discoidin domain receptor 1 (DDR1), a kinase target implicated in fibrosis and other diseases, in 21 days. Four compounds were active in biochemical assays, and two were validated in cell-based assays. One lead candidate was tested and demonstrated favorable pharmacokinetics in mice.
Today's Top 5
5. New Prosthetic Leg Combating Phantom Pain
4. Digital Health Flourishing Overseas
3. FDA Approves First Hypoglycemic Rescue Pen
2. Meru Health Offering "The New Standard of Mental Healthcare"
. @MeruHealth introduces 'The New Standard of Mental Healthcare' along with— Daniel Kraft, MD (@daniel_kraft) September 18, 2019
publication of peer-reviewed 1-year treatment In which enrolled patients had clinically significant reductions in symptoms of depression & anxiety https://t.co/7rgOpTg7p9 #digitalhealth #mentalhealth
1. Hydrogel Use in Modeling Cardiac Tissue
Hydrogel Mimics of Heart Tissue to Study Cardiac Reshaping Following Aortic Valve Implantation #Card #fitness #health #training #healthy #healthylifestyle #cardio #healthyliving #healthylife #medicine #healthcare #AI #cardioworkout #cardiologia #card https://t.co/jek10Y0bqm pic.twitter.com/UgLpzF9jV2— HeartIn 🗯️ (@HeartIn_net) September 20, 2019