Bilateral Paraneoplastic Orbital Myositis Associated With Malignant Melanoma and Multiple Myeloma

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Ophthalmic Plast Reconstr Surg. 2021 Dec 6. doi: 10.1097/IOP.0000000000002105. Online ahead of print.


Paraneoplastic extraocular muscle enlargement has been reported in a small number of patients with cancers including breast or lymphoma, usually presenting with bilateral multiple muscle involvement. Such myositis may be autoimmune. Furthermore, orbital inflammation is a recognized complication of immune-modulation therapy used to treat melanoma, such as ipilimumab. Extraorbital myositis has been described in myeloma, and polymyositis in melanoma. We present a case of bilateral, asymmetrical extraocular muscle enlargement with spontaneous resolution in a patient with simultaneous new diagnoses of metastatic malignant melanoma and multiple myeloma. A similar episode 7 months before diagnosis also resolved spontaneously. The authors believe this to be the first reported case of paraneoplastic orbital myositis associated with multiple myeloma or untreated malignant melanoma.

PMID:34873125 | DOI:10.1097/IOP.0000000000002105