Abstract Perspective: Genicular Artery Embolization for Osteoarthritis Related Knee Pain: A Systematic Review and Qualitative Analysis of Clinical Outcomes


“Knee osteoarthritis (OA) is a common cause of pain and a leading cause of disability. As part of a systematic review and qualitative analysis, our research evaluated published literature on a novel minimally invasive outpatient treatment for OA related knee pain, genicular artery embolization (GAE). In three single arm studies 186 knees were treated among 133 patients. Most patients 94% (174/186) had mild to moderate OA, while 6% (12/186) had severe OA. In the mild to moderate OA cohort, average visual analog scale (VAS) pain scores demonstrated a statistically significant and durable decrease in each of the studies when compared to baseline. A small cohort of patients with severe OA showed a transient decrease in VAS scores, but this was not sustained. While there are many limitations of currently available data given heterogenous inclusion/exclusion criteria, varied definitions of clinical success, and lack of randomization, these studies do suggest that GAE is a promising treatment for osteoarthritis related knee pain in patients with mild to moderate osteoarthritis. Further research is required to evaluate the safety, efficacy, and durability of this intervention in treating patients with OA related knee pain.”

-Dr. Yan Epelboym, study author