READ THE ORIGINAL ABSTRACT HERE.
It has been reported that patients with rheumatoid arthritis (RA), accompanied by large joint involvement were difficult to achieve remission. However, there have been no randomized controlled trials or cohort-based study which compare the efficacy of different biologic disease-modifying antirheumatic drugs (bDMARDs) in the RA patients with large joint involvement. This calls for the need of developing a better treatment strategy for RA with large joint involvement. In the present study, we investigated the efficacy of anti-IL-6 receptor antibody (aIL-6) and other bDMARDs, such as TNF-inhibitor and CTLA4-Ig in the treatment of RA in patients with knee joint involvement. Interestingly, we found that treatment with aIL-6 significantly increased ΔCDAI in patients with knee joint involvement, compared to other bDMARDs at 12 weeks by multivariate analysis. However, there was no significant difference in ΔCDAI improvement between aIL-6 and other bDMARDs in patients without swollen knee joints. ΔCDAI levels were equally increased in patients with shoulder and elbow joint involvement. Therefore, this study revealed that aIL-6 was more effective in the patients with RA who have knee joint involvement, compared to other bDMARDs.
– Dr. Maeda, study author